Trusted Information for Healthy Pregnancies
Pregnancy Outcomes
What is the Impact of Depression During Pregnancy?
Jul 12th
In a recent study by Gerardin and colleagues, the authors note that more research has been done to demonstrate the consequences of postpartum depression than depression during pregnancy (also called antenatal or prenatal depression). Infants born to mothers with depression during pregnancy have been demonstrated to have lower scores on motor behavior and more crying [...]
Serotonin Reuptake Inhibitors and Fertility (Part 2): What Can Basic Science Tell Us?
Jul 5th
Serotonin (5-HT) is one of the neurotransmitters involved in mood regulation and has been implicated in the development of mood and anxiety disorders. Serotonin transporters (SERT) facilitate the transfer of serotonin into neurons; serotonin reuptake inhibitor (SSRI) antidepressants bind to these transporters and appear to exert their effect on mood by inhibiting the reuptake of [...]
Zolpidem (Ambien) in Pregnancy: Is it Safe?
Nov 22nd
It is estimated that up to 95% of women experience some type of sleep disturbance during pregnancy. While for many women the insomnia is relatively benign and may respond to simple interventions, other women experience more severe insomnia which has a significant impact on their quality of life and ability to function. While zolpidem (Ambien), [...]
ACOG Focuses on Smoking Cessation in Pregnant and Postpartum Women
Nov 10th
In the November issue of Obstetrics & Gynecology, The American College of Obstetricians and Gynecologists (ACOG) has issued recommendations to providers regarding efforts to support smoking cessation in pregnant and postpartum women. The article states that while about half of women smokers stop smoking during pregnancy, about 13% of women in the United States continue [...]
Valproic Acid and the Risk of Major Malformations
Jun 14th
Previous studies have indicated that infants exposed to valproic acid in pregnancy are at increased risk for a range of malformations, including neural tube defects. While these studies have shown an association between valproic acid and various malformations, they have been limited in their ability to quantify the risk of certain, less common malformations. To [...]
Intrauterine Cannabis Exposure Affects Fetal Growth
Jan 21st
Although the risks of smoking tobacco while pregnant are well documented and well publicized to the general population, women continue to smoke cigarettes during pregnancy. Smoking cigarettes is known to increase a woman’s risk of having a low-birth weight baby and increases the risk of preterm delivery. While clinicians often ask about and discourage tobacco [...]
Use of the Emsam Patch (Selegiline) in Pregnancy
Dec 14th
A clinician asks: “Is there any data on the use of the Emsam patch in pregnancy?”
There is very little information on the reproductive safety of the MAOI-B inhibitor, selegiline, which is the active ingredient of the Emsam patch. While animal studies have failed to reveal any evidence of teratogenicity, the medical literature includes [...]
Panic Disorder Increases the Risk of Adverse Birth Outcomes
Dec 8th
Anxiety often results in the activation of the sympathetic nervous system. This activation is commonly known as the “fight or flight response”; symptoms may include increased heart rate, shortness of breath, perspiration, chest pain, and nausea or diarrhea. Activation of the fight or flight response is also associated with the activation of numerous other responses [...]
SSRIs and PPHN: A Review of the Data
Nov 10th
In 2006, Chambers and colleagues published an article linking SSRI use during late pregnancy to an increased risk of persistent pulmonary hypertension in the newborn (PPHN). Since that time, several other reports have been published which have examined the association between SSRI antidepressants and PPHN. Here is a summary of the findings to date:
Chambers et [...]